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Pros and Cons for Treatment of Menopause Symptoms

This table was formulated by the Hormone Foundation, the public education affiliate of the Endocrine Society

 

Symptom Treatment Pros and Cons of Treatment
Hot flashes Vitamin E

Pros: May reduce number and severity of hot flashes
Cons: No toxicity of Vitamin E; some people get headaches

Clonidine Pros: Effective treatment; extra dosage can be given at night to prevent awakening
Cons: Tiredness or dizziness in some women
Megestrol acetate Pros: Effective progestin treatment for hot flashes
Cons: Weight gain; not studied well in women who have had breast cancer
SSRI drugs Pros: Shown to be effective for hot flashes and also for depression
Cons: Causes mood changes; can affect sex drive
Estrogen* Pros: Very effective at relieving hot flashes; also helps prevent vaginal thinning; prevents bone loss
Cons: Increased risk of breast cancer; increased risk of uterine cancer if estrogen is taken without progesterone; increased risk of blood clots
     
Dry vagina and painful intercourse Vaginal moisturizers Pros: Instantly effective moisturizer; over-the-counter solution
Cons: Some people don't like these products, because of consistency or smell; does not thicken the vaginal lining
Water-soluble lubricants Pros: Instantly effective moisturizer; over-the-counter solution
Cons: Some people don't like these products because of their consistency or smell; does not thicken the vaginal lining
Vaginal estrogen ring Pros: Helps keep vaginal tissue from thinning
Cons: Small increased risks compared with higher doses of estrogen
Estrogen* (by mouth) Pros: Helps keep vaginal tissue from thinning; also helps prevent bone loss; very effective against hot flashes
Cons: Increased risk of breast cancer; increased risk of uterine cancer if estrogen is taken without progesterone; increased risk of blood clots
     
Bone loss Vitamin D Pros: Helps body absorb calcium
Cons: Large amounts of vitamin D can cause build-up of calcium in blood, which could lead to heart and lung problems
Calcitonin Pros: Slows bone breakdown
Cons: Headaches, dizziness, diarrhea, lack of desire for eating, nose bleeds (with nasal form)
Bisphosphonates Pros: Very effective against bone loss
Cons: Common to have gastrointestinal problems when taking these drugs; can cause injury to esophagus unless taken with lots of water while sitting upright or standing
Tamoxifen Pros: Lowers risk of breast cancer; reduces risk of fractures
Cons: Increases risk of uterine cancer, blood clots; more hot flashes; irregular vaginal bleeding
Raloxifene Pros: May lower risk of breast cancer; prevents fractures
Cons: Increases risk of blood clots; hot flashes; leg cramps
Estrogen* Pros: Helps prevent vaginal tissue from thinning; also helps prevent bone loss; very effective against hot flashes
Cons: Increased risk of breast cancer; increased risk of uterine cancer if estrogen is taken without progesterone; increased risk of blood clots
     
Depression and mood changes Counseling Pros: Can be empowering to understand your physical and mental challenges at this time of life and discuss them with a mental health expert
Cons: Can be expensive
SSRI drugs Pros: Shown to be effective for hot flashes and also for depression
Cons: May cause mood changes; can affect sex drive
Estrogen* Pros: Very effective at preventing bone loss and preventing fractures; very effective at preventing hot flashes; prevents vaginal tissue thinning; may reduce the risk of dementia (in younger menopausal women taking HT for 10 years or more)
Cons: Increased risk of dementia; increased risk of breast cancer; increased risk of uterine cancer if estrogen is taken without progesterone; increased risk of blood clots; increased risk of dementia (in women 65 years and older taking HT for five years or less)
     
Breast cancer risk Estrogen* Pros: Women who have had breast cancer or who are at high risk for having breast cancer probably should not take estrogen (estrogen's benefits are discussed throughout this table)
Cons: Increased risk of breast cancer; increased risk of uterine cancer if estrogen is taken without progesterone; increased risk of blood clots
Tamoxifen Pros: Lowers risk of breast cancer; reduces risk of fractures
Cons: Increases risk of uterine cancer, blood clots; more hot flashes; irregular vaginal bleeding
Raloxifene Pros: May lower the risk of breast cancer; prevents fractures
Cons: Increases risk of blood clots; more hot flashes; leg cramps

*Short-term goals of estrogen treatment are different from the long-term goals. Short-term therapy is designed to relieve symptoms; long-term therapy helps to prevent bone loss. If you take hormones for less than three to five years, the risks are relatively low. If you are concerned about bone loss and are thinking about taking hormone therapy for more than five years, consult with your doctor to see whether hormone therapy or an alternative treatment is best for you.

To find a reproductive endocrinologist please visit our online physician referral or call 1-800-HORMONE (800-467-6663).

Editor:

Robert B. Jaffe, MD
Fred Gellert Professor of Reproductive Medicine and Biology
University of California, San Francisco; San Francisco, CA

Last Review: January 2005